|
|
|
|
Compared with treatment with placebo,quinine reduced the frequency of cramps and sleep disturbance,but not the average cramp severity.Thirteen of 27 patients had at least a 50%reduction in the number of cramps while receiving quinine;the response was usually seen within 3 days.There was evidence of a mild increase in side effects while subjects received quinine.Vitamin E was not effective in reducing leg cramp frequency, severity,or sleep disturbance.Conclusions-Quinine sulfate,but not vitamin E,is superior to placebo in the treatment of nocturnal leg cramps. |
|